EndoTODAY 내시경 교실
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[Mucolytics]
1. Yao 선생님의 추천
상부위장관 내시경 시술의 국가간 차이 (Uedo N. Digest Endosc 2016)에 대한 논문에 mucolytics 부분이 있었습니다.
일본에서는 mucolytics/deforming agents를 거의 항상 사용하는군요.
Yao 선생님의 Development of an e-learning system 논문에 실린 내용을 옮깁니다.
The correct preparation for endoscopic examination is mandatory to minimize time and effort during the procedure, i.e., the removal of mucus and froth from the mucosal surface. Thirty minutes before the procedure, patients are asked to drink a mixture of water with mucolytic and defoaming agents. The formula in Japan is 100 mL of water with 20,000 U Pronase® (Kaken Pharmaceutical, Tokyo, Japan), 1 g of sodium bicarbonate, and 10 mL of dimethylpolysiloxane (20 mg/mL, Horii Pharmaceutical Ind., Osaka, Japan). However, Pronase® is not available for use in all countries. An alternative mixture comprises 100 mL of water mixed with 2 mL of acetylcysteine (200 mg/mL Parvolex®, Celltech, Slough, UK; or Mucomyst, Bristol-Myers Squibb, New York, NY, USA), and 0.5 mL activated dimethicone (40 mg/mL, Infacol®, Forest Laboratories, Dartford, UK).
2. 일본 조기위암 내시경 진단 가이드라인
Mucolytics가 강하게 추천되었습니다.
[References]
1) Development of an e-learning system. Kenshi Yao, et al. Gastric Cancer 2017
© 일원내시경교실 바른내시경연구소 이준행. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng.
